- Playing As
- Use on poisoned stationary targets like monsters and units stunned by her for maximum damage.
- Lead your enemy when targeting with to ensure the hit.
- Playing Against
- Be wary of Cassiopeia's damage potential with when she has you poisoned.
- Turn away from Cassiopeia when she is casting to be slowed instead of stunned.
- Ability Usage
- Mastery Usage
- is good on Cassiopeia because, in conjunction with and/or , can proc the damage very easily without putting her at too much risk.
- works well as a means of escape. If can deal enough damage in a short amount of time, she can proc the speed boost and get away safely.
- is another good mastery as it adds an extra DoT to the already potent one has.
- Item Usage