Chalice of Harmony is an advanced item in League of Legends.
- 50% base health regeneration = 150
- is gold efficient without its passive, and gold efficient after applying it.
- most benefits champions who have a large need for mana, such as , , , , and . It can be used by any mana champion as a source of emergency sustain, however.
- Champions who have no real use for ability power or cooldown reduction are not necessarily encouraged to buy this item over , as Tear's upgrade offers far more relevant stats to mana-hungry AD champions than Chalice's upgrade, .