Chalice of Harmony most benefits champions who have a large need for mana, such as Karthus, Orianna, Anivia, Kassadin, and Swain. It can be used by any mana champion as a source of emergency sustain, however.
Champions who have no real use for ability power or cooldown reduction are not necessarily encouraged to buy this item over Tear of the Goddess, as Tear's upgrade Manamune offers far more relevant stats to mana-hungry AD champions than Chalice's upgrade, Athene's Unholy Grail.
New Unique Passive: Grants 100% base health regen per 5 seconds if your current health percentage is lower than your current mana percentage. Grants 100% base mana regen per 5 seconds if your current mana percentage is lower than your current health percentage.