|"Regrettably, I must retire in order to find a digestive."
- is gold efficient.
- For the item to be gold efficient, the active must be worth at least 173g.
The activated damage triggered on-ability effects, such as and spell vamp, and was treated as a single-target spell for the purpose of these effects. It does not apply champion-specific effects (such as ).
The Doom debuff could be removed with Quicksilver.
- It was best used to initiate fights, as it amplified all subsequent magic damage the target takes. It was worth noting that that the damage amplifier would increase magic damage dealt from all sources, not just the holder of Deathfire Grasp.
- was a great choice on burst mages who had the potential to kill enemies in a single spell combo, such as and .
- was a better option when more than one member of a team dealt primarily magic damage, such as an AP support.
- When champions and was removed and reworked into its current iteration.
was originally added, it was far too powerful on certain
- Its previous behavior has now been reinstated and slightly modified into .
- In the V220.127.116.11 patch, the item was reimplemented with a new functionality.
-  , , (now called ), and were released as a quartet of "sister items" that share similar features, specifically having an active ability and a gold-generating item in their recipe.
- Abilities that caused you to deal increased damage also increase the damage dealt by
(e.g. and ).
- Also, Deathfire Grasp's debuff "Doom" stacked additively with other sources of percentile received damage amplification (for example, )
- However it stacked multiplicatively with all sources of percentile dealt damage amplification (for example, and ), as long as the incoming damage was magical.
- This item was removed because, while originally intended as a way to allow AP assassins and burst mages to deal with tanks, was actually used most of time to completery obliterate squishy champions without allowing them a chance to survive, even forcing champions like into a playstyle that wasn't originally intended for them. As such, Riot removed Deathfire Grasp to allow them to better balance burst mages and AP assassins. They created to replace Deathfire Grasp as the go-to item for burst APs.