- His name comes from two sources: Proto-Germanic *mundo "hand, protection" & unrelated Ibero-Romance mundo "world" (like in Spanish, Portuguese, etc.).
- Dr. Mundo's dance references the titular character from House, M.D. in turn dancing to Fight the Power by Public Enemy.
- A side-by-side comparison be seen here.
- Dr. Mundo is one of five champions who use health as a resource for abilities, the other four being , , , and .
- Of them he himself is the only one whose ultimate ability has a cost, that being 25% of his current health.
- Mundo is apparently lactose intolerant.
- He is not actually a doctor, but he thinks he is.
- "Mundo smash!" references The Hulk from Marvel Comics.
- "Mundo will go where he pleases" might be referencing Duke Nukem ("I'll go where I please, and please where I go.")
- Zaun can be seen in the background.
- He resembles The Hulk from Marvel Comics.
- In the Brazilian server, this skin is called "Dr. Mulko", as a reference to this fact.
- He was conceived as a player request.
- He features in the game's Mac version trailer.
- He was released in celebration of Harrowing 2010 along with:
- He is dressing as himself.
- Other than
wearing a Mundo mask, masks and costumes depicting several champions can be seen in the background:
- He resembles Leatherface from The Texas Chainsaw Massacre.
- He shares the double name theme with:
- This skin is a reference to Lucha libre.
- He has a great resemblance to WWE's The Ul
- He shares this theme with: