Grievous Wounds is a debuff that reduces self-healing by 40%.
Sources
Champion abilities
Katarina's 
Death Lotus applies Template:Cctip to all targets hit for 3 seconds.
Varus' 
Hail of Arrows creates an area of Desecrated Ground that afflicts enemies with Template:Cctip while they remain inside.
Items
- Morellonomicon's passive causes all magic damage to apply Template:Cctip for 4 seconds if the target is below 40% health.
- Executioner's Calling makes all physical damage apply Template:Cctip for 3 seconds
- Mortal Reminder makes all physical damage apply Template:Cctip for 5 seconds
Spells
- Ignite applies Template:Cctip and deals 50 + (20 × level) true damage over the next 5 seconds.
Global Auras
- The Murder Bridge map reduces all outsourced healing and regeneration effects by 50%.
Patch history
- Now only affects self-healing from healing from all sources.
- Healing reduction reduced to 40% from 50%.