- Heimerdinger was designed by Ezreal (person).
- Heimerdinger is voiced by Dennis Collins Johnson, who also voices Gangplank and Taric.
- His name is a combination of the names of , a physicist known for being the "father" of the atomic bomb, and , one of the fathers of quantum physics.
- Heimerdinger's walking animation is often referred to by players and Rioters alike as "derpy", highlighted as one of his unique qualities, as shown in this video.
- Heimerdinger has the lowest armor of all champions at level 18 at 61.
- Prior to his rework, Heimerdinger was only able to place 2 H-28G Evolution Turrets. However, it was possible to have 3 active by utilizing a glitch with Syndra's Force of Will. If 2 turrets were placed and one of them was targeted for Force of Will, Heimerdinger could place one more turret during the stasis.
- Heimerdinger was the only champion who could restore turrets' health, with his passive Techmaturgical Repair Bots. As of his rework, the ability no longer affects turrets.
- Activating UPGRADE!!! will give Heimerdinger a buff and the tooltip reads "Harder, Better, Faster, Stronger" , This is a reference to a Daft Punk song by the same name.
- His walking quote "For great science" is a reference to the internet meme "For great justice ", which originated from the Engrish translation of the game Zero Wing.
- His other walking quote, "Back, you dirty ape, back!" is a reference to .
- Rumble's League Judgment contains a quote from Heimerdinger, who insults him in a technical manner: "The probability of your continued existence is rapidly approaching zero."
- Alien Invader Heimerdinger is a reference to
, a comedic alien invasion movie.
- The skin changes the look of his turrets to retro sci-fi rayguns.
- Piltover Customs Heimerdinger changes the look of his turrets to engines.
- The skin's art background has Hot Rod Corki's flying vehicle.
- Blast Zone Heimerdinger's Chinese artwork is used as an image to show that the League of Legends store is under maintenance.
- Heimerdinger created Master Yi's goggles, the Seven Lenses of Insight.
- Heimerdinger also created Corki's Reconnaissance Operations Front-Line Copter (ROFL copter).