- Heimerdinger is a
of and 's last names.
- His given name Cecil comes from Caecilius, a Roman surname, from caecus "blind".
- Heimerdinger's alternate/old walk is referred to as 'derpy'.
- Using emotes will make Heimerdinger alternate between his regular walk and his 'derpy' walk.
- While 'Harder, Better, Faster, Stronger'. is active Heimerdinger gains a cosmetic buff that reads
- If Heimerdinger scores a Pentakill he will gain the cosmetic buff Eureka!
- This buff references ' sudden revelation, only in Heimerdinger's case his own came after the mass murder of the enemy team.
- Heimerdinger is the sixth champion to have more than four abilities, the others being , , , , , and .
- "For great science" references .
- "Back, you dirty ape, back!" references .
- "Raise your what?" references ヽ༼ຈل͜ຈ༽ﾉ raise your dongers by Michael 'Imaqtpie' Santana from Team Dignitas.
- "The probability of your continued existence is rapidly approaching zero" was used in 's League Judgement.
- "Not enough variables... hmm... not nearly enough variables" references from ("Too many variables")
- "42... there's just something about that number" and "Aha, 42, I knew it! Now--- er, what was the question again?" reference .
- In Brazilian localization Heimerdinger has a joke referencing .
- "I prefer a battle of wits, but you're unarmed!" references ("I would challenge you to a battle of wits, but I see you are unarmed!")
- [ |
- He resembles .
- [ |
- He references
- turns into a retro sci-fi raygun.
- [ |
- He is basically his Classic self but covered in soot after something blew up on his face.
- is charred but still functional.
- He appears when the game's store is under maintenance.
- [ |
- turns into a car engine.
- He shares this theme with and [ |.
- The Hot Rod in question can be seen in the background.
- [ |
- He is wearing a and holding a bottle of radioactive liquid.
- A sign featuring not being allowed can be seen to his left.
- He might be referencing and/or .
- Heimerdinger created  as well as 's Reconnaissance Operations Front-Line Copter (ROFL Copter) 's Seven Lenses of Insight
- Heimerdinger is seen as a role model by and as a sellout by .
- Piltover recognizes Heimerdinger's contributions to technological advancement and techmaturgical research.