- Death Defied will always trigger after revival effects ( , ) and if Karthus is killed by the Nexus Obelisk.
- Karthus will still benefit from cooldown reduction during Death Defied.
- The sight is granted around Wall of Pain's pillars but not the wall itself.
- Wall of Pain can only affect any given unit once per cast.
- Wall of Pain is not considered terrain for .
- Defile also restores mana if Karthus destroys an enemy structure.
- Defile will automatically toggle on during .
- Requiem's channel is telegraphed to all enemy champions by green beam of light that descends on all targets.
- The beam will be applied to untargetable enemies, although they will not take damage if they are still untargetable when the damage is applied.
- If Requiem's channel is interrupted in some fashion it goes on full cooldown and its cost is not refunded.
- Karthus cannot cast Requiem if duration is less than 3 seconds.