Not all Noxian commanders condone their colleagues' callousness, though they at least turn a blind eye.
Kayn may be a possible reference to Ling Yao, a character from the anime Fullmetal Alchemist: Brotherhood. Both characters share similarities in that a superhuman entity reside in them which vies for control of their bodies (Rhaast, a Darkin inside Kayn and Greed, a Homunculus inside Ling Yao). Moreover, Kayn shares quite a lot of similarities in character design with Ling Yao.
Kayn could also similar to Masane Amaha, a character from the anime Witchblade (An adaptation of the the comics of the same name). Both wield weapons that are sentient in nature and try to take control of their bodies (Kayn's Scythe contains Rhaast, and Masane's gauntlet contains an unnamed entity), as well as both of them possessing supernatural powers.