If Dredge Line deals the killing blow, it will drag Nautilus to where the target was upon death, as if the skill had hit terrain.
Titan's Wrath and Riptide are excellent farming tools when used together, as they each deal a good amount of area of effect damage.
Titan's Wrath resets your autoattack timer, so timing it right after a basic attack can allow for a quick second hit.
If you are farming minions, Staggering Blow can be a great tool to increase your last-hitting capabilities due to its free bonus-damage.
Be careful when chasing an enemy under the turret with Dredge Line. If you miss and hit the turret, you'll end up horribly off position.
Be sure about your position while using Riptide. You must be close enough to catch the opponent because this spell is pretty slow in animation.
The range onDredge Line is a bit further than the indicator shows. Experiment on terrain to see how far you can be to proc the skill shot.
Dredge Line is a fantastic method of travel, especially at higher levels. When running around between lanes, use it on terrain to pull yourself along faster. The same goes for fleeing; if a fight goes bad, run for the nearest turret or open terrain, and pull yourself to it for a quick escape. For a quick start after recalling or respawning, latch on to your nexus.
Mark squishy/high priority targets with Depth Charge in order to give your team a good chance to kill them. It's also useful for stopping channels, such as Katarina'sDeath Lotus. Also, the squishy targets tend to be at the back their team so you'll be able to hit their entire team with the pass through damage instead of only one target with the explosion damage
Remember that Staggering Blow is an immobilization, which means it does nothing to stop channeled ultimates.
Titan's Wrath has a very long CD time, especially early before Nautilus gets it to high levels and has more CDR. Try running out the clock on the ability, then hit him during that cooldown window.
Titan's Wrath can add up to significant damage over the course of a team fight. Consider diverting a couple of attacks to break the shield when you see him use it.
Nautilus can be used as a CC heavy support like Leona with a harder to land initiation but with more damage and CC , getting caught by his combo and his lane partner can be even deadlier than getting grabbed by Blitzcrank.
Nautilus is one of the few tanks that has strong magic damage, so consider building magic resistance.
While Nautilus has burst damage, this is moot when his abilities are on cooldown. Try to engage him after he has used several abilities.
Dredge Line draws Nautilus to terrain, so when running from him, try and stay away from terrain, or a miss may still bring him closer.
With enough ability power Nautilus can burst down an squishy target (ADC , APC) like a mage , but including an overwhelming amount of CC
He will combo with Dredge Line, followed by Riptide (that will likely hit twice) , all while he has his shield up, and finish the it landing an an unavoidable Depth Charge , that has even more harsher CC and a devastating blow of damage.
Nautilus will think twice of following the attack if you avoid Dredge Line , as it will be much harder for him to combo , and Dredge Line has quite a damaging blow , that Nautilus can't hope to miss, as he is just left with Depth Charge to close the gap , and loosing a significant amount of damage.
Nautilus has early mana problems , force him to overuse his abilities.
Stand still when he uses his Riptide to prevent the extra magic damage the spell deals when it moves.
Even standing still it's very likely to get hit by two explosions if you are using any champion bigger than Teemo or Lulu
Getting hit by 3 explosions is impossible if you are still but almost confirmed to hit if you are moving.