- Nunu is the name of one of the developer's dogs. He also uses it as a nickname for his wife.
- In thermodynamics, refers to a state where the temperature of a system is at the theoretical lowest possible limit: approximately -459.67 degrees Fahrenheit, -273.15 degrees Celsius, or zero Kelvin.
- Nunu was designed by Guinsoo.
- The Yeti's name is Willump.
- After changes to Zilean's Chrono Shift AP ratio, Absolute Zero has the highest single AP scaling of 2.5 damage per 1 AP in the game.
- Nunu's base health at level 18 is the highest of any champion at 2381.
- Nunu is voiced by Cristina Ulloa, who also voices Amumu and Annie. Willump is voiced by Brian Sommer, who voices Tryndamere and Warwick.
While similar, Sejuani and Bristle only drop one soul between them. This had led to a joke among the community that Sejuani has ginger hair in reference to the internet meme that gingers have no soul. 
- Nunu's taunt is a reference to from .
- Nunu's joke is a reference to famous quote, "Speak softly and carry a big stick."
- Grungy Nunu skin is a direct reference to two characters, Oscar the Grouch and the Cookie Monster.
- In the Chinese Sasquatch Nunu skin he is wearing a .
- Nunu Bot skin is a reference to Angry Goran's Nunu Bot series.
- The screens in the artwork also references the series, displaying the words "Push" and "Uploading A.I.".
- Demolisher Nunu skin is a reference to "Master Blaster" from the movie Mad Max Beyond Thunderdome.
- TPA Nunu skin is related to "Taipei Assassins", who have won the League of Legends Season 2 World Championship finals.