Runes can only be purchased from the Riot Store with Influence Points. Runes cannot be purchased with Riot Points. Each rune grants a small bonus in a specific category, which stack upon each other to grant larger bonuses.
Glyphs, marks, and seals stack up to 9 for increased effect, and quintessences stack up to 3.
Purchasing the maximum useful number of every type of tier 3 rune (9 of each glyph, mark and seal, and 3 of each quintessence) would cost 389,916 IP, encouraging specialization.
The number of runes a player can have is limited to approximately 1230. Note that getting the appropriate maximums of each tier 3 rune comes out to 684, however, this amount can be exceded if you purchased either special event runes or purchased more than the maximum usable amount (ie. 9 quintessences) of a specific rune before patch 1.59.
Additional Rune Pages may also be bought from the Riot Store with Riot Points or Influence Points, up to a max of 20.
There are four kinds of Runes, with three levels each, a Summoner can use:
It is also important to note that some runes are "primary", while others are called "secondary" and provide lesser bonuses. Given a certain kind of rune, it will be primary in either marks, glyphs or seals, and secondary in the other two rune types. So, all kind of runes have one primary type for them and two secondary types. The aura shrouding a rune of a certain effect will denote which rune type it is considered primary - for example, ability power runes will have a blue aura showing that it is Glyphs that specialise in them.
Although Quintessences have the max possible effect, you may only have three instead of the nine marks, seals, or glyphs - this means one quintessence should be equal to three or more runes in order to qualify as a "Primary" Quintessence. The following Quintessences have an effect equal to or greater than three primary runes:
The Tier of a rune represents its relative power (i.e. the extent of the bonuses it offers), and is visible in the top-left of the pop-up when mousing over it.
Tier 1 or "Lesser" runes are dark and faded with visible scratches and chips except for Quintessences, which are simply purple.
Tier 2 don't have prefixes, they are slightly brighter and are not tattered; Quintessences now have gold faces and purple backgrounds. You can buy them starting at level 10.
Tier 3 or "Greater" runes are brightly lit; Quintessences are completely covered in gold. You can buy them starting at level 20.
It is important to note that you cannot buy a Tier 3 rune before you reach level 20
Summoners are able to use a rune per level of power in League of Legends, and they keep their Runes in a tome called a Runebook. Before a match begins, a Summoner will be able to choose from up to twenty different rune configurations they have previously set in their Runebook. This allows the Summoner to have quick flexibility in choosing a Runebook configuration best suited for whatever champion they might use in any of Valoran's Fields of Justice.
For the purpose of estimating the runtime of search algorithms in the space of possible rune pages, it may be interesting to enumerate the number of unique possible combinations of runes. Since the position of any particular rune on the rune page does not influence its statistics, the order within the rune page can be disregarded and it only matters how many of which types of runes occur on the rune page. In the mathematical sense, this means we are looking for the number of combinations with repetition (since any type of rune can occur multiple times, in fact as often as there are slots) of length 9 from the sets of marks, seals and glyphs and of length 3 from the set of quintessences, respectively. The problem can be solved with binomial coefficients. Assuming only Tier 3 runes are chosen and no slots may be left blank:
19 different T3 Marks constitute c(19+9-1, 9) = 4,686,825 combinations of marks.
24 different T3 Seals constitute c(24+9-1, 9) = 28,048,800 combinations of seals.
22 different T3 Glyphs constitute c(22+9-1, 9) = 14,307,150 combinations of glyphs.
33 different T3 Quintessences constitute c(33+3-1, 3) = 6,545 combinations of quintessences
The number of unique combinations of entire rune pages is the product of those:
12,309,936,280,199,112,555,000,000 or ~1.23*10^25 or 12.31 septillion.
If an algorithm was to evaluate one billion of these combinations per second, it would still require ~ 390.08 million years to evaluate all of them, making exhaustive approaches practically impossible.
Either preselections of eligible runes or heuristics have to be employed instead.