- Ryze was designed by Ezreal and Guinsoo.
- Ryze is one of five champions voiced by Adam Harrington, the other four being Karthus, Kassadin, Mordekaiser, and Shaco.
- He was the first champion released prior Season One to obtain a League Judgement.
- Ryze's original cost was 1350 . He was lowered to 450 on April 12, 2011.
- The scroll that Ryze keeps on his back is seen behind an overturned chair in the Mac Launch preview video.
- In his lore it is said that the scroll which Ryze keeps on his back is indestructible, but in the video "A Twist of Fate", his scroll is cut by Nocturne. However, later in the cinematic, the scroll seems to have reformed. Whether this is because the scroll will always repair itself or not is left unstated, and is up to speculation.
- So far he appeared in all cinematic trailers.
- Ryze shares a quote with Jinx saying "Zap"
- Human Ryze is one of the four Collector's Edition skins, the other champions with this distinction are Alistar, Kayle and Annie. It can no longer be obtained, as it was a pre-order skin.
- Uncle Ryze is a reference to used in recruitment.
- In the Chinese Uncle Ryze art, that Ryze carries on its back is replaced with other text.
- Tribal Ryze is often compared/considered to look like , the God of the Sky and Ruler of the Olympian gods, from Greek Mythology.
- Triumphant Ryze is only available to those who win official competition matches. The skin was previously known as "Champion" and "Trophy".
- Pirate Ryze's splash art features several other champions that share the pirate theme. From left to right, these champions are: Bilgerat Rumble, Fiddle Me Timbers, Bilgewater Katarina, Buccaneer Tristana and Bilgewater Swain.
- Ryze was the first champion to have 9 skins.
- Ryze was the first champion to have 2 Harrowing skins, from 2010 & 2012.