Unit-targeting is the most basic targeting paradigm an ability can have - abilities using this targeting type require a valid target to cast on within range. What constitutes a 'valid' target varies from spell to spell; this list has been separated into subsets depending on what the spell can be used on, with several abilities belonging to more than one group.
Certain spells should not be confused as having the alternate targeting paradigm self-targeting - abilities listed here have the user as just one of the potential valid targets instead of the only one.
Uniquely, 
Janna's 
Eye of the Storm is the only unit-targeted-exclusive ability that can function on allied towers. 
Azir's 
Arise! can also function on towers, but is predominantly a ground-targeted ability. Terrain-targeted abilities can target towers as well and unlike ground-targeted abilities cannot be cast on ground. Hence they are being listed as subcategory of unit-targeting.
Champion Abilities
Self-targeted
Braum's Stand Behind Me- Galio's Bulwark
- Janna's
- Karma's Defiance and Inspire
- Kayle's Divine Blessing and Intervention
- Lee Sin's Safeguard
- Lissandra's Frozen Tomb
- Lulu's Help, Pix!, Wild Growth and Whimsy
- Mordekaiser's Creeping Death
- Morgana's Black Shield
- Nami's Ebb and Flow and Tidecaller's Blessing
- Nidalee's Primal Surge
- Nunu's Blood Boil
- Orianna's Command: Protect
- Taric's Starlight's Touch
- Zilean's Time Warp and
Ally-targeted
- Azir's Disc of the Sun and Shifting Sands
- Braum's Stand Behind Me
- Galio's Bulwark
- Janna's
- Jax's Leap Strike
- Karma's Defiance and Inspire
- Kayle's Divine Blessing and Intervention
- Katarina's Shunpo
- Lee Sin's Safeguard
- Lulu's Help, Pix!, Wild Growth and Whimsy
- Mordekaiser's Creeping Death
- Morgana's Black Shield
- Nami's Ebb and Flow and Tidecaller's Blessing
- Nidalee's Primal Surge
- Nunu's Blood Boil
- Orianna's Command: Protect
- Rek'Sai's Void Rush
- Shen's Stand United
- Soraka's Astral Infusion
- Taric's Starlight's Touch
- Tahm Kench's Devour
- Zilean's Time Warp and
Enemy-targeted
- Alistar's Headbutt
- Anivia's Frostbite
- Annie's Disintegrate
- Akali's Mark of the Assassin and Shadow Dance
- Brand's Conflagration and Pyroclasm
- Caitlyn's Ace in the Hole
- Cassiopeia's Twin Fang
- Cho'Gath's Feast
- Darius' Noxian Guillotine
- Diana's Lunar Rush
- Elise's Neurotoxin, Rappel and Venomous Bite
- Evelynn's Ravage
- Fiddlesticks' Dark Wind, Drain and Terrify
- Fizz's Urchin Strike
- Gangplank's Parrrley
- Garen's Demacian Justice
- Irelia's Bladesurge and Equilibrium Strike
- Janna's Zephyr
- Jarvan IV's Cataclysm
- Jax's Leap Strike
- Jayce's Thundering Blow and
- Karma's Focused Resolve and Renewal
- Kayle's Reckoning
- Kassadin's Null Sphere
- Katarina's Bouncing Blades and Shunpo
- Kha'Zix's Taste Their Fear and Evolved Enlarged Claws
- LeBlanc's Sigil of Malice and Mimic Sigil of Malice
- Lee Sin's Dragon's Rage
- Lissandra's Frozen Tomb
- Lucian's Piercing Light
- Lulu's Help, Pix! and Whimsy
- Malphite's Seismic Shard
- Malzahar's Malefic Visions and Nether Grasp
- Maokai's Twisted Advance
- Master Yi's Alpha Strike
- Miss Fortune's Double Up
- Mordekaiser's Children of the Grave
- Nami's Ebb and Flow
- Nasus' Wither
- Nautilus' Depth Charge and Dredge Line
- Nocturne's Paranoia and Unspeakable Horror
- Nunu's Consume and Ice Blast
- Olaf's Reckless Swing
- Pantheon's Aegis of Zeonia and Spear Shot
- Poppy's Diplomatic Immunity and Heroic Charge
- Quinn's Vault
- Rek'Sai's Furious Bite
- Rammus' Puncturing Taunt
- Ryze's Rune Prison and Spell Flux
- Shaco's Two-Shiv Poison
- Shen's Vorpal Blade
- Singed's Fling
- Skarner's Impale
- Swain's Decrepify and Torment
- Syndra's Unleashed Power
- Tahm Kench's Devour
- Talon's Cutthroat
- Taric's Dazzle
- Teemo's Blinding Dart
- Tristana's Buster Shot and Explosive Charge
- Trundle's Subjugate
- Urgot's Acid Hunter (lock-on) and Hyper-Kinetic Position Reverser
- Vayne's Condemn
- Veigar's Primordial Burst
- Vi's Assault and Battery
- Viktor's Siphon Power
- Vladimir's Transfusion
- Volibear's Frenzy
- Warwick's Hungering Strike and Infinite Duress
- Wukong's Nimbus Strike
- Xin Zhao's Audacious Charge
- Yasuo's Sweeping Blade
- Zed's Death Mark
- Zilean's Time Warp
Terrain-targeted
Items
Ally-targeted
Enemy-targeted
Summoner Spells
Ally-targeted
Enemy-targeted
Template:Ability types