Untargetable refers to units in a state where targeted spells such as Rammus's Puncturing Taunt and LeBlanc's Sigil of Malice cannot be cast on the unit. Nontargeted spells such as Karthus's Requiem will also have no effect; an exception being Soraka's Wish. Additionally, they cannot be targeted by auto attacks.
- Kalista's Fate's Call completely removes her Oathsworn ally from the game for 4 seconds or until the ally dashes to a position, whichever comes first.
- Shaco's Hallucinate completely removes him from the game for a short time before the clone spawns. This can dodge everything, including aoe's, ignite ticks, and ability procs. Leashes continue attached to him after he clones.
- Tahm Kench's Devour swallows a target enemy minion, neutral monster, ally champion or enemy champion with three stacks of An Acquired Taste for up 5 seconds at max rank (enemy champions take half duration of the effect).
These break all forms of leashes and makes the unit untargetable and provides immunity to all DoT effects. DoTs continue to deal damage once the invulnerability ends if they have not expired yet, they are not cleansed.
- Bard's Tempered Fate makes all units within the casted location's radius untargetable and invulnerable for 2.5 seconds.
- Ekko's Chronobreak makes him untargetable for 0.5 seconds while channeling back to where he was 4 seconds ago.
- Aatrox's Blood Well makes him untargetable for 3 seconds while reviving.
- Kled's Skaarl the Cowardly Lizard briefly makes him untargetable when he dismounts.
- Lissandra's Frozen Tomb makes her untargetable for 2.5 seconds if cast on herself.
- Zilean's Chrono Shift makes a champion untargetable for 2 seconds before revival.
- 's passive makes your champion untargetable for before revival.
- 's active ability makes your champion untargetable for 2.5 seconds.
- If a champion dies, they will be untargetable.
Projectiles fired before the untargetability starts will have no effect. They will still take damage from DoTs such as and Malzahar's Malefic Visions and will not break leashes such as Fiddlesticks's Drain and Morgana's Soul Shackles. They will not be damaged by delayed abilites such as Zilean's Time Bomb and Fizz's Chum the Waters, but will be damaged by Vladimir's Hemoplague and Zed's Death Mark
- Elise's Rappel makes her untargetable for 2 seconds or until it is recast on an enemy target.
- Fizz's Playful makes him untargetable for 0.75 seconds or until he uses Trickster.
- Vladimir's Sanguine Pool makes him untargetable for 2 seconds.
- Maokai's Twisted Advance makes him untargetable while moving to the target.
- Master Yi's Alpha Strike makes him untargetable for a short time while in flight.
- Zed's Death Mark makes him untargetable while moving to the target.
- Rek'Sai's Void Rush makes her untargetable while moving to a targeted Tunnel.
- Kayle's Intervention grants the immunity to damage for the duration. DoTs that are still taking effect will continue their damage once Intervention ends, and the target can be affected by all forms of CC while it lasts. The unit can still be targeted by attacks and damaging abilities, but will not receive any damage from them.
- Kindred's Lamb's Respite will prevent any further damage when units inside hit 10% of their max. health, but are unable to regenerate or restore health, and can still be affected by attacks and abilities. All forms of CC will still affect as normal.
- Tryndamere's Undying Rage will prevent any further damage when he hits 1 hitpoint, but he can still be targeted by attacks and abilities. All forms of CC will still affect him.
Note: The Nexus Obelisk ignores all Damage Invulnerability effects and can damage and kill any champion while the effect lasts. If a unit is untargetable, however, the Obelisk will not fire at it.