Okay, so everyone knows that the Shadow Isles is the home of some of the more....... moster-movie-esque Champions. But seriously, I know a lot of you have seen the "Four Horsemen of the Apocalypse" referrence.
War=:Hecarim He is the "Shadow of War"
Death=Thresh : The newest champion in the making just screams "Grim Reaper", and his passive benefits from the death of others
Famine= ?: I really don't know who famine is, though it's safe to assume that he/she/it will still come from the Shadow Isles
I get that this is most likely redundant information, but hey, just sharing thoughts
edit: Removed Karthus and replaced him with Thresh