I would be quite interested to see what would happen if there were a mode where you'd hit the random button in champion select, and get 5 random abilities. Totally unrelated to each other, and from different champions, but the key bindings would stay the same - one passive, one Q, one W, one E, and one ult.
What would be some of the best, worst, and weirdest combinations you could think of? I know these will be constructed and not random, but all of this is hypothetical anyway.
Some of my personal favorites: