|Champion||Background||Strategy||Skins & Trivia|
- Vayne's first name is Shauna.
- Like many other hunters of the supernatural, Vayne's character concept is inspired by
, the protagonist from Bram Stoker's 1897 novel, Dracula.
- Vayne's name and past are possible references to DC Comics character .
- Vayne may also be a reference to the DC Comics character , due to the similarities between their weapons and pasts.
- Vayne bears some resemblance to the main character from the game .
- Vayne is one of the 9 champions who do not have a single skill that scales off ability power; along with Darius, Draven, Garen, Kalista, Olaf, Riven, Talon and Zed.
- Vayne's Silver Bolts, is a reference to the belief that supernatural creatures, particularly , are vulnerable to weapons made from silver.
- Vayne is the only champion to currently have a defense rating of 1.
- Vayne's dance is inspired by the Gun Kata . A side-by-side comparison can be seen here.
- Vayne is the first champion who shares her title with a skill name, followed by Zyra.
- Vayne is the first champion to always have a quote play out when learning a skill.
- Vayne's quote "On wings of night." is similar to Shyvana's quote "On wings of fury."
- Vayne's quote when using her ultimate, "The die is cast" is a reference to Julius' Caesar phrase "Alea Iacta Est" .
- This splash art got updated in Patch 4.15.
- In the old splash art, there is a tombstone labeled "URF" in reference to Urf, the Manatee, and Yorick's shovel in the background.
- It is likely a reference to the from the Underworld film series.
- Vayne is wearing clothing.
- This skin resembles a certain pop star, .
- Vayne shares the Dragonslayer theme with Jarvan IV, Pantheon and Braum.
- Dragonslayer Vayne's appearance is reminiscent of Capcom's Monster Hunter series.
- It is a tribute to Valentine's Day 2012.
- Dr. Mundo is shown shot down in the background with a bouquet of roses, and Vayne herself is reading a macaroni card made by him.
- In its Chinese artwork, Jack of Hearts Twisted Fate can be seen in the background.
- She shares this theme with Ashe and Varus.
- A tribute skin for Season 3 winners, SK Telecom.
- She shares this theme with Zed, Jax, Zyra and Lee Sin.
- There is speculation that Vayne is secretly investigating the activities of LeBlanc and the Black Rose organization .